Why the study?
Are IL6R polymorphisms and chromosome 4 loci associated with atrial fibrillation in white and African American populations?
Are IL6R polymorphisms and chromosome 4 loci associated with atrial fibrillation in white and African American populations?
This study identifies a genetic association between IL6R polymorphism and atrial fibrillation in whites, and confirms the chromosome 4 locus association in African Americans.
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IL6R variants may influence AF risk in whites; extends chromosome 4 locus to African Americans but leaves clinical translation open.
In a community-based cohort meta-analysis, we identified genetic association in IL6R with AF in whites. Additionally, we demonstrated that the chromosome 4 locus known from recent genome-wide association studies in whites is associated with AF in African Americans.
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Schnabel et al. (2011) studied this question.
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