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January 18, 2011JAMA1,121 citationsOpen Access

Use of Florbetapir-PET for Imaging β-Amyloid Pathology

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CCChristopher M. Clark

Key Points

  • Determine whether florbetapir-PET molecular imaging can accurately detect and quantify the presence and density of β-amyloid pathology in the living human brain.
  • Assessed in vivo florbetapir-PET molecular imaging to evaluate its correlation with β-amyloid pathology.
  • Florbetapir-PET imaging correlated directly with the presence and density of β-amyloid pathology.
  • Results confirm that molecular imaging can identify Alzheimer-related β-amyloid pathology in human brains during life.

Abstract

Florbetapir-PET imaging was correlated with the presence and density of β-amyloid. These data provide evidence that a molecular imaging procedure can identify β-amyloid pathology in the brains of individuals during life. Additional studies are required to understand the appropriate use of florbetapir-PET imaging in the clinical diagnosis of Alzheimer disease and for the prediction of progression to dementia.

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Cite This Study

Christopher M. Clark (2011) studied this question.

synapsesocial.com/papers/69d8b24cce048d2571bedd83https://doi.org/10.1001/jama.2010.2008
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