Key Points
- This review summarizes the structural architecture, signaling networks, and functional roles of striated muscle cytoskeletal assemblies in cardiac and skeletal systems.
- Synthesized molecular and physiological findings on striated muscle cytoarchitecture from literature.
- Evaluated filament assemblies including sarcomeric systems, intermediate filaments, costameres, intercalated discs, and myotendinous junctions.
- Characterized the coordinated roles of thin (actin), thick (myosin), titin, and nebulin filaments in driving sarcomeric contraction.
- Identified intermediate filaments and costameres as essential anchors linking contractile units to internal organelles and the cellular membrane to preserve structural integrity.
- Linked mutations in diverse muscle cytoskeletal proteins directly to the molecular pathogenesis of human myopathies.
Structured PICO
PPopulationCardiac and skeletal striated muscles
This review provides a comprehensive overview of the muscle cytoskeleton, highlighting its components, functions, and connections to human myopathies.