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Determine how spatial firing patterns in entorhinal grid cells and hippocampal place cells adapt when detecting and encoding novel versus familiar environments.

October 8, 2012Proceedings of the National Academy of SciencesOpen Access

Grid cell firing patterns signal environmental novelty by expansion

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Determine how spatial firing patterns in entorhinal grid cells and hippocampal place cells adapt when detecting and encoding novel versus familiar environments.
Electrophysiologically recorded spatial firing patterns of grid cells during transitions between familiar and novel testing environments.
Simultaneously monitored hippocampal place cell activity to evaluate remapping dynamics and field properties.
Environmental novelty induced an increase in grid cell scale and a reduction in firing regularity.
Grid cell firing fields reverted to their original scale as environments transitioned from novel to familiar.
Simultaneously recorded place cells underwent spatial remapping and displayed a smaller, transient field expansion.

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Implication

Electrophysiological study demonstrates grid cell expansion in animals exposed to novel environments, indicating a dynamic neural mechanism for spatial novelty detection.

Cite This Study

Barry et al. (2012) studied this question.

synapsesocial.com/papers/69d8be35ce048d2571bedf84 https://doi.org/10.1073/pnas.1209918109

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Implication

Electrophysiological study demonstrates grid cell expansion in animals exposed to novel environments, indicating a dynamic neural mechanism for spatial novelty detection.

Grid cell firing patterns signal environmental novelty by expansion

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Implication

Cite This Study

Grid cell firing patterns signal environmental novelty by expansion

Key Points

Discussion

Implication

Cite This Study

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