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To review the translation mechanisms of circular RNAs and characterize the functional roles of circular RNA-encoded proteins in human cancer.

February 15, 2020Molecular CancerOpen Access

Translation and functional roles of circular RNAs in human cancer

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To review the translation mechanisms of circular RNAs and characterize the functional roles of circular RNA-encoded proteins in human cancer.
Narrative synthesis of recent literature on circular RNA biogenesis, identification methods, and non-coding regulatory functions.
Evaluation of molecular mechanisms underlying cap-independent translation initiation and peptide generation in malignant cells.
Circular RNAs translate into functional peptides via cap-independent initiation driven by internal ribosome entry sites (IRES) and N6-methyladenosine (m6A) modifications.
Proteins encoded by circular RNAs play active roles in regulating cellular physiology and modulating human cancer progression.

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Review reveals cap-independent translation of circular RNAs in human cancer, highlighting a novel layer of the hidden proteome driving oncogenesis.

Lei et al. (2020) studied this question.

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Review reveals cap-independent translation of circular RNAs in human cancer, highlighting a novel layer of the hidden proteome driving oncogenesis.