What question did this study set out to answer?

To assess the long-term impact of local consolidative therapy compared to maintenance therapy or observation in patients with oligometastatic non-small-cell lung cancer responsive to initial systemic treatment.

May 8, 2019Journal of Clinical OncologyOpen Access

Local Consolidative Therapy Vs. Maintenance Therapy or Observation for Patients With Oligometastatic Non–Small-Cell Lung Cancer: Long-Term Results of a Multi-Institutional, Phase II, Randomized Study

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Authors

DGDaniel R. GomezCedars-Sinai Medical Center CTChad TangThe University of Texas MD Anderson Cancer Center JZJianjun ZhangThe University of Texas MD Anderson Cancer Center

Discussion

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Implication

Randomized trial demonstrates improved progression-free and overall survival with local consolidative therapy in oligometastatic non-small-cell lung cancer, supporting aggressive local treatment.

Key Points

To assess the long-term impact of local consolidative therapy compared to maintenance therapy or observation in patients with oligometastatic non-small-cell lung cancer responsive to initial systemic treatment.
Multi-institutional, phase II randomized clinical trial.
Enrolled patients with oligometastatic non-small-cell lung cancer (NSCLC) that did not progress following front-line systemic therapy.
Randomly assigned participants to receive either local consolidative therapy (LCT) or maintenance therapy/observation (MT/O).
Local consolidative therapy led to a significant prolongation in progression-free survival (PFS) compared to maintenance therapy or observation.
Overall survival (OS) was significantly prolonged in the local consolidative therapy group relative to maintenance therapy or observation.

Cite This Study

Gomez et al. (2019) studied this question.

synapsesocial.com/papers/69d8bf78183921ebcaae382b https://doi.org/10.1200/jco.19.00201

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Implication

Randomized trial demonstrates improved progression-free and overall survival with local consolidative therapy in oligometastatic non-small-cell lung cancer, supporting aggressive local treatment.

Local Consolidative Therapy Vs. Maintenance Therapy or Observation for Patients With Oligometastatic Non–Small-Cell Lung Cancer: Long-Term Results of a Multi-Institutional, Phase II, Randomized Study

Discussion

Member takes

Implication

Key Points

Cite This Study

Local Consolidative Therapy Vs. Maintenance Therapy or Observation for Patients With Oligometastatic Non–Small-Cell Lung Cancer: Long-Term Results of a Multi-Institutional, Phase II, Randomized Study

Discussion

Member takes

Implication

Key Points

Cite This Study

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