A six-gene interferon score may prove useful as a biomarker for diagnosis and treatment efficacy assessment in pediatric inflammatory diseases.
An assessment of six ISGs can be used to define a spectrum of inflammatory diseases related to enhanced type I interferon signaling. If future studies demonstrate that the IS is a reactive biomarker, this measure may prove useful both in the diagnosis and the assessment of treatment efficacy.
Rice et al. (2016) studied this question.