Inborn errors of immunity (IEI) are generally classified into primary immunodeficiency disorders and disorders of immune dysregulation. The latter include conditions characterized by autoimmunity, autoinflammation, and/or lymphoproliferation, which may also be associated with recurrent infections [ 1 ]. Presence of these opposing immune features leads to significant diagnostic and management challenges.
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Wijerathne et al. (2026) studied this question.
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