Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
August 11, 2025Paediatrics & Child Health

A descriptive analysis of autoimmune cytopenias in children with inborn errors of immunity

View Full Paper
Ask AI
Bookmark
Share

Authors

JLJae-hwan LewSSSneha SureshCCCatherine Corriveau‐Bourque

Discussion

Loading...

Member takes

Overview

Descriptive study reveals variability in autoimmune cytopenias across immunophenotypic categories in children with IEI.

Key Points

  • Autoimmune cytopenias are commonly observed across different immunophenotypes in children with inborn errors of immunity, showing variability in type.
  • Thrombocytopenia occurred frequently in combined (53.8%), syndromic (59%), and immune regulatory disorders (63.6%) among children studied.
  • Neutropenia was primarily found in phagocytic (71.4%) and immune regulatory disorders (63.7%), indicating specific associations with cytopenias.
  • The findings highlight the importance of investigating both immunodeficiency and autoimmune symptoms for better patient management.

Cite This Study

Lew et al. (2025) studied this question.

synapsesocial.com/papers/68a360e00a429f79733294f0https://doi.org/10.1093/pch/pxaf056
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Evaluation of non-infectious warning signs in children with inborn errors of immunity2025
  2. 2Germline genetic testing uncovers a high frequency of inborn error of immunity diagnoses in children with single and multi-lineage immune cytopenias in a large US cohort2025 · 2 citations
  3. 3Clinical Overview of 100 Patients with Inborn Errors of Immunity at National Defense Medical College2026
  4. 4Clinical and genetic spectrum of inborn errors of immunity: a retrospective study on outcomes at a single center2026
  5. 5Chronic autoimmune cytopenias in pediatric age group: Clinical features and outcome2026