Probiotic as a Potential Gut Microbiome Modifier for Stroke Treatment: A Systematic Scoping Review of In Vitro and In Vivo Studies

Chatuthanai Savigamin; Chatpol Samuthpongtorn; Nuttida Mahakit; Tanawin Nopsopon; Julie A. Heath; Krit Pongpirul

doi:10.3390/nu14173661

September 5, 2022NutrientsOpen Access

Probiotic as a Potential Gut Microbiome Modifier for Stroke Treatment: A Systematic Scoping Review of In Vitro and In Vivo Studies

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Key Points

Assess the therapeutic potential of probiotic supplementation to modify the gut microbiome and improve stroke outcomes in preclinical models.
Systematic scoping review analyzing in vitro and in vivo experimental models evaluating probiotic interventions for stroke.
Probiotic supplementation is associated with decreased cerebral volume and increased neurological scores in animal models.
Treatment with probiotics suppresses the post-stroke inflammatory response.
Validation in diverse clinical populations is required to confirm whether these cognitive and neurological benefits translate to humans.

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Implication

Systematic scoping review shows probiotic supplementation reduces brain injury and inflammation in stroke models, indicating gut-targeted therapeutic potential.

Abstract

There are potential cognitive benefits of probiotic supplementation, especially among animal models, on decreasing cerebral volume, increasing neurological score, and decreasing the inflammatory response. However, further investigation is needed to validate these conclusions in various populations.

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Savigamin et al. (2022) studied this question.

synapsesocial.com/papers/69d8c54d52654bb436d19e0a https://doi.org/10.3390/nu14173661

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Probiotic as a Potential Gut Microbiome Modifier for Stroke Treatment: A Systematic Scoping Review of In Vitro and In Vivo Studies

Key Points

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Implication

Abstract

Discussion

Cite This Study

Probiotic as a Potential Gut Microbiome Modifier for Stroke Treatment: A Systematic Scoping Review of In Vitro and In Vivo Studies

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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