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April 29, 2011American Journal of Respiratory Cell and Molecular BiologyOpen Access

An Official American Thoracic Society Workshop Report: Features and Measurements of Experimental Acute Lung Injury in Animals

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Authors

GMGustavo Matute‐BelloNational Heart Lung and Blood InstituteGDGregory P. DowneyNational Jewish HealthBMBethany B. MooreUniversity of Michigan

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Implication

Expert consensus reveals core diagnostic criteria for acute lung injury in animal models, highlighting the need for standardized experimental definitions.

Key Points

  • To establish expert consensus on the primary features that characterize acute lung injury in animal models and determine the most appropriate measurements to evaluate them.
  • Convened an expert committee using a structured Delphi consensus methodology.
  • Distributed iterative questionnaires to an international panel of experimental lung injury specialists to rank diagnostic features and measurement validity.
  • Identified four cardinal features of experimental acute lung injury: histological tissue injury, alveolar-capillary barrier disruption, inflammatory response, and physiological dysfunction.
  • Recommended that at least three of the four cardinal features be documented to confirm the presence of experimental acute lung injury in animal models.
  • Categorized evaluative techniques into 'very relevant' and 'somewhat relevant' tiers, advising researchers to include at least one very relevant metric per assessed feature.

Cite This Study

Matute‐Bello et al. (2011) studied this question.

synapsesocial.com/papers/69d8ca832c39562886ae2bc8https://doi.org/10.1165/rcmb.2009-0210st
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