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Our meta-analysis identified several risk factors for amputation in DFU patients, including the male sex, a smoking history, a history of foot ulcers, osteomyelitis, gangrene, a lower body mass index, and a higher white blood cell count. Once gangrene occurs, the risk of amputation rapidly increases.
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SHILAP Revista de lepidopterología
PLoS ONE
Fujian Medical University
Zhongshan Hospital of Xiamen University
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Lin et al. (Wed,) studied this question.