July 1, 1978Circulation

Coronary arterial spasm and Prinzmetal's variant form of angina induced by hyperventilation and Tris-buffer infusion.

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Why the study?

Does hyperventilation plus Tris-buffer infusion induce coronary arterial spasm in patients with Prinzmetal's variant angina, and does diltiazem suppress these reactions?

Population

9 patients with Prinzmetal's variant angina

Design

Case_series

Follow-up

Immediate (during or within 5 minutes after procedure)

Authors

HYHirofumi YasueGeneral Cardiology MNMichinobu NagaoTokyo Women's Medical University SOShingo OmoteHoshigaoka Medical Center

Discussion

Member takes

Implication

Supports hyperventilation-Tris provocation for spasm in variant angina; leaves open diltiazem prophylaxis efficacy in larger trials.

Structured PICO

Does hyperventilation plus Tris-buffer infusion induce coronary arterial spasm in patients with Prinzmetal's variant angina, and does diltiazem suppress these reactions?

Population

9 patients with Prinzmetal's variant angina

Intervention

Vigorous hyperventilation for 5 minutes immediately after a 5-minute infusion of 100 ml of Tris-buffer (pH 10), with a subset of 5 patients receiving oral diltiazem 90 mg 2 hours prior

Outcome

Chest pain with ischemic changes in the electrocardiogram and coronary arterial spasmsurrogate

Hyperventilation combined with Tris-buffer infusion reliably provokes coronary artery spasm in patients with Prinzmetal's variant angina, an effect that can be prevented by prophylactic administration of diltiazem.

Cite This Study

Yasue et al. (1978) studied this question.

synapsesocial.com/papers/69d8ce2cf39dfae3cad17e58 https://doi.org/10.1161/01.cir.58.1.56

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