What question did this study set out to answer?

To examine whether Ginsenoside Ro alleviates cognitive deficits and neuroinflammation in an APP/PS1 transgenic mouse model of Alzheimer's disease.

February 24, 2025SHILAP Revista de lepidopterologíaOpen Access

Ginsenoside Ro ameliorates cognitive impairment and neuroinflammation in APP/PS1 mice via the IBA1/GFAP-MAPK signaling pathway

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Authors

TLTianyao LiGuangzhou University of Chinese Medicine JCJiaxin ChenOntario Forest Research Institute ZXZhouyuan XieGuangzhou University of Chinese Medicine

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Implication

Preclinical study reveals Ginsenoside Ro alleviates cognitive impairment and neuroinflammation in APP/PS1 mice, suggesting a viable therapeutic mechanism for Alzheimer's disease.

Key Points

To examine whether Ginsenoside Ro alleviates cognitive deficits and neuroinflammation in an APP/PS1 transgenic mouse model of Alzheimer's disease.
Treated APP/PS1 transgenic mice with Ginsenoside Ro to evaluate its neuroprotective efficacy.
Assessed cognitive outcomes, neuroinflammatory biomarkers, and activity within the IBA1/GFAP-MAPK signaling cascade.
Ginsenoside Ro treatment significantly alleviates cognitive deficits and suppresses neuroinflammation in APP/PS1 mice.
Neuroprotective and anti-inflammatory outcomes are mediated via the down-regulation or modulation of the IBA1/GFAP-MAPK signaling pathway.

Cite This Study

Li et al. (2025) studied this question.

synapsesocial.com/papers/69d8d0b013e0539d74bed94f https://doi.org/10.3389/fphar.2025.1528590

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Implication

Preclinical study reveals Ginsenoside Ro alleviates cognitive impairment and neuroinflammation in APP/PS1 mice, suggesting a viable therapeutic mechanism for Alzheimer's disease.

Ginsenoside Ro ameliorates cognitive impairment and neuroinflammation in APP/PS1 mice via the IBA1/GFAP-MAPK signaling pathway

Discussion

Member takes

Implication

Key Points

Cite This Study

Ginsenoside Ro ameliorates cognitive impairment and neuroinflammation in APP/PS1 mice via the IBA1/GFAP-MAPK signaling pathway

Discussion

Member takes

Implication

Key Points

Cite This Study

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