What question did this study set out to answer?

To compare the cumulative probability of false-positive results and the stage distribution of incident breast cancer after 10 years of annual versus biennial screening mammography.

October 18, 2011Annals of Internal Medicine

Cumulative Probability of False-Positive Recall or Biopsy Recommendation After 10 Years of Screening Mammography

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To compare the cumulative probability of false-positive results and the stage distribution of incident breast cancer after 10 years of annual versus biennial screening mammography.
Prospective cohort study utilizing data from 7 mammography registries within the Breast Cancer Surveillance Consortium.
Analyzed 169,456 women aged 40 to 59 years undergoing initial screening mammograms (1994–2006) and 4,492 women diagnosed with incident invasive breast cancer (1996–2006).
Estimated 10-year cumulative probabilities of false-positive recalls and biopsy recommendations, alongside incident cancer stage distributions, for annual versus biennial regimens.
Ten-year cumulative probability of at least one false-positive recall when starting at age 40 was 61.3% (95% CI, 59.4% to 63.1%) with annual screening versus 41.6% (95% CI, 40.6% to 42.5%) with biennial screening.
Ten-year cumulative risk of false-positive biopsy recommendation starting at age 40 was 7.0% (95% CI, 6.1% to 7.8%) for annual screening compared with 4.8% (95% CI, 4.4% to 5.2%) for biennial screening.
Biennial screening was associated with a non-statistically significant increase in late-stage cancer diagnoses compared to annual screening (absolute increase of 3.3 percentage points [95% CI, −1.1 to 7.8] for ages 40–49 and 2.3 percentage points [95% CI, −1.0 to 5.7] for ages 50–59).

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Implication

Prospective cohort study observes reduced false-positive recalls with biennial versus annual mammography in women aged 40 to 59, indicating a trade-off with late-stage cancer risks.

Cite This Study

Hubbard et al. (2011) studied this question.

synapsesocial.com/papers/69d8d158f39dfae3cad18009 https://doi.org/10.7326/0003-4819-155-8-201110180-00004

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Implication

Prospective cohort study observes reduced false-positive recalls with biennial versus annual mammography in women aged 40 to 59, indicating a trade-off with late-stage cancer risks.

Cumulative Probability of False-Positive Recall or Biopsy Recommendation After 10 Years of Screening Mammography

Key Points

Discussion

Implication

Cite This Study

Cumulative Probability of False-Positive Recall or Biopsy Recommendation After 10 Years of Screening Mammography

Key Points

Discussion

Implication

Cite This Study

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