Discussion reveals the roles of T-cell receptors and natural killer receptors in tumor recognition by gamma delta T cells, suggesting improvements for immunotherapy.
The dissection of the molecular mechanisms underlying tumor-cell recognition by γδ T-cells is crucial to improve their performance in cancer immunotherapy. Here, we discuss the controversy around the relative contributions of the γδ T-cell receptor (TCR) and natural killer receptors (NKRs) to tumor-cell targeting by γδ T cells.
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Correia et al. (2013) studied this question.
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