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January 1, 1992Arteriosclerosis and Thrombosis A Journal of Vascular Biology

Prediction of mechanical properties of human atherosclerotic tissue by high-frequency intravascular ultrasound imaging. An in vitro study.

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Why the study?

Does intravascular ultrasound appearance relate to the biomechanical properties of human atherosclerotic tissue?

Structured PICO

Does intravascular ultrasound appearance relate to the biomechanical properties of human atherosclerotic tissue?

P

Population

43 atheroma caps obtained from the abdominal aortas of 22 patients at autopsy

I

Intervention

High-frequency intravascular ultrasound imaging (6F, 20-MHz transducer) and mechanical testing

O

Outcome

Uniaxial unconfined compression stiffness (static stiffness) and creep timesurrogate

Intravascular ultrasound appearance of atherosclerotic plaques is significantly related to their biomechanical behavior, particularly when calcium deposits are present.

Discussion

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Implication

IVUS-plaque stiffness correlation in this animal model is hypothesis-generating; leaves open human validation before clinical consideration.

Cite This Study

Lee et al. (1992) studied this question.

synapsesocial.com/papers/69d8d20533ca018b39ae41e0 https://doi.org/10.1161/01.atv.12.1.1

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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

1Fibrosis, lipids, and calcium in human atherosclerotic plaque. In vitro differentiation from normal aortic walls by ultrasonic attenuation.preclinical · 1985 · 79 citations
2Structure-dependent dynamic mechanical behavior of fibrous caps from human atherosclerotic plaques.preclinical · 1991 · 372 citations
3Plaque Characterization of Atherosclerotic Coronary Arteries by Intravascular Ultrasoundpreclinical · 1990 · 51 citations
4Relaxation and Creep Quasilinear Viscoelastic Models for Normal Articular CartilageOriginal Research · 1984 · 59 citations