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Synapse
May 27, 2009Circulation335 citationsOpen Access

Regulatory T Cells Ameliorate Angiotensin II–Induced Cardiac Damage

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HKHeda KvakanMKMarkus KleinewietfeldFQFatimunnisa Qadri

Key Points

  • This research aims to understand how regulatory T cells (Tregs) can reduce cardiac damage caused by angiotensin II.
  • Transferred regulatory T cells to evaluate effects on cardiac health
  • Assessed electric remodeling and blood pressure changes
  • Investigated the immunosuppressive effects independent of blood pressure
  • Regulatory T cells significantly ameliorated cardiac damage without affecting blood pressure
  • Improved electric remodeling observed due to Treg cell activities
  • Insights gained could inform new therapies targeting immune system manipulation

Abstract

Immunosuppressive effects of transferred Treg cells ameliorated cardiac damage and accounted for the improved electric remodeling independently of blood pressure-lowering effects. Our results provide new insights into the pathogenesis of hypertensive cardiac damage and could therefore lead to new therapeutic approaches that involve manipulation of the immune system.

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Cite This Study

Kvakan et al. (2009) studied this question.

synapsesocial.com/papers/69d8d259ade63f05b9bed9f0https://doi.org/10.1161/circulationaha.108.832782
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1CD4+CD25+Foxp3+ regulatory T cells suppress cardiac fibrosis in the hypertensive heart2011 · 82 citations
  2. 2Hypertension-Driven Regulatory T-Cell Perturbations Accelerate Myocardial Ischemia-Reperfusion Injury2023 · 21 citations
  3. 3Tregs delivered post-myocardial infarction adopt an injury-specific phenotype promoting cardiac repair via macrophages in mice2024 · 64 citations
  4. 4An emerging role of regulatory T-cells in cardiovascular repair and regeneration2020 · 43 citations
  5. 5Dysfunctional and Proinflammatory Regulatory T-Lymphocytes Are Essential for Adverse Cardiac Remodeling in Ischemic Cardiomyopathy2019 · 300 citations