Key result
Adoptive transfer of regulatory T cells significantly ameliorated Coxsackievirus B3-induced cardiac fibrosis in mice, a protective effect mediated mainly through the secretion of IL-10.
Why the study?
Does adoptive transfer of regulatory T cells reduce Coxsackievirus B3-induced cardiac fibrosis in BALB/c mice?
Does adoptive transfer of regulatory T cells reduce Coxsackievirus B3-induced cardiac fibrosis in BALB/c mice?
p-value: p=<0.05
Adoptive transfer of regulatory T cells protects against Coxsackievirus B3-induced cardiac fibrosis in a mouse model via IL-10 secretion.
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Hypothesis-generating for Treg therapy in viral myocarditis; human trials needed before clinical translation.
Cao et al. (2013) studied Coxsackievirus B3-induced cardiac fibrosis. Adoptive transfer of Regulatory T cells (Tregs) vs. Mock transfer / Isotype antibody was evaluated on Severity of cardiac fibrosis (assessed by collagen volume fraction and collagen I mRNA expression) (p=<0.05). Adoptive transfer of regulatory T cells significantly ameliorated Coxsackievirus B3-induced cardiac fibrosis in mice, a protective effect mediated mainly through the secretion of IL-10.
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