Key result
Adoptive transfer of CD4+CD25+ regulatory T lymphocytes significantly improved left ventricular contraction and attenuated adverse cardiac remodeling 14 days after myocardial infarction in mice.
Why the study?
Does adoptive transfer of regulatory T lymphocytes attenuate myocardial infarction-induced ventricular remodeling in a murine model?
Does adoptive transfer of regulatory T lymphocytes attenuate myocardial infarction-induced ventricular remodeling in a murine model?
p-value: p=<0.05
Adoptive transfer of regulatory T cells attenuates post-myocardial infarction cardiac remodeling and dysfunction in mice, likely by modulating the inflammatory response.
No takes yet. Share an insight, caveat, or question.
Treg transfer may blunt post-MI inflammation and remodeling; leaves open clinical translation.
Matsumoto et al. (2011) studied Myocardial infarction (n=13). CD4+CD25+ regulatory T lymphocytes vs. Saline was evaluated on Left ventricular contraction (fractional shortening) and infarct ratio (p=<0.05). Adoptive transfer of CD4+CD25+ regulatory T lymphocytes significantly improved left ventricular contraction and attenuated adverse cardiac remodeling 14 days after myocardial infarction in mice.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: