Why the study?
Does adoptive regulatory T-cell transfer improve cardiac inflammation, remodeling, and function in mice with CVB3-induced myocarditis?
Population
Mice with coxsackievirus B3 (CVB3)-induced myocarditis
Comparison
Syngeneic regulatory T cells applied… vs PBS (CVB3 + PBS mice)
Design
Preclinical
Authors
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May attenuate inflammation and fibrosis in murine CVB3 myocarditis; leaves open clinical translation of Treg therapy.
Does adoptive regulatory T-cell transfer improve cardiac inflammation, remodeling, and function in mice with CVB3-induced myocarditis?
Adoptive transfer of regulatory T cells in the inflammatory phase of viral myocarditis protects the heart against inflammatory damage and fibrosis in a mouse model.
Pappritz et al. (2018) studied this question.
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