June 8, 2010Circulation

Regulatory T Cells Protect Mice Against Coxsackievirus-Induced Myocarditis Through the Transforming Growth Factor β–Coxsackie-Adenovirus Receptor Pathway

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Why the study?

Does adoptive transfer of regulatory T cells protect mice against coxsackievirus B3-induced myocarditis?

Structured PICO

Does adoptive transfer of regulatory T cells protect mice against coxsackievirus B3-induced myocarditis?

Population

Mice challenged with intraperitoneal coxsackievirus B3 (model of human myocarditis and dilated cardiomyopathy), as well as HL-1 cells and neonatal cardiac myocytes.

Intervention

Intravenous injection of Carboxyfluorescein diacetate succinimidyl ester-labeled Regulatory T cells (Tregs) once every 2 weeks for 3 doses prior to viral challenge.

Comparator

Intravenous injection of naïve CD4(+) T cells or PBS.

Outcome

Survival rates, virus titers, and inflammatory scores in the heart.surrogate

Adoptive transfer of regulatory T cells protects against coxsackievirus-induced myocarditis in mice by downregulating the coxsackie-adenovirus receptor via TGF-beta.

Discussion

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Implication

Supports Treg transfer in murine viral myocarditis; hypothesis-generating and should not change clinical practice.

Cite This Study

Shi et al. (2010) studied this question.

synapsesocial.com/papers/6a7c1e2bae178dbf17c65d82 https://doi.org/10.1161/circulationaha.109.893248

Topics

Myocarditis

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Bookmark

Regulatory T Cells Protect Mice Against Coxsackievirus-Induced Myocarditis Through the Transforming Growth Factor β–Coxsackie-Adenovirus Receptor Pathway

Structured PICO

Discussion

Implication

Cite This Study

Topics

Regulatory T Cells Protect Mice Against Coxsackievirus-Induced Myocarditis Through the Transforming Growth Factor β–Coxsackie-Adenovirus Receptor Pathway

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Topics

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