Key result
Mice lacking CD8+ T cells showed enhanced survival and reduced myocarditis compared to immunocompetent mice, with CD4ko and beta 2Mko mice showing 10- and 180-fold increases in the 50% lethal dose.
Population
Normal and immuno-compromised transgenic knockout mice
Comparison
Coxsackievirus B3 infection via intraperitoneal… vs Immunocompetent C57BL/6 mice compared with…
Design
Preclinical
Follow-up
2 to 3 weeks
Authors
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Suggests T-cell immunopathology in murine CVB3 myocarditis; leaves open translation to human disease and therapy.
Effect estimate: 10- and 180-fold increase in LD50
Both CD4+ and CD8+ T cells play a strong immunopathologic role in CVB3-induced myocarditis, highlighting a complex balance between antiviral immune response and myocardial injury.
Henke et al. (1995) studied Coxsackievirus B3-induced myocarditis. CD4 and CD8 T cell deficiency (knockout or depletion) vs. Immunocompetent C57BL/6 mice was evaluated on 50% lethal dose (LD50) and myocarditis severity (10- and 180-fold increase in LD50). Mice lacking CD8+ T cells showed enhanced survival and reduced myocarditis compared to immunocompetent mice, with CD4ko and beta 2Mko mice showing 10- and 180-fold increases in the 50% lethal dose.
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