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April 1, 1981The Journal of Immunology

Sex-related differences in the rapid production of cytotoxic spleen cells active against uninfected myofibers during Coxsackievirus B-3 infection.

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Population

BALB/c mice (male and female)

Comparison

Immunization with a cardiotropic strain of… vs Immunization with a noncardiotropic strain of…

Design

Preclinical

Follow-up

6 days

Authors

SHSally A. HuberUniversity of VermontLJL P JobUniversity of VermontKAK.R. AuldUniversity of Vermont Medical Center

Discussion

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Implication

Sex differences in antiviral immunity may shape myocarditis pathogenesis; hypothesis-generating and should not change practice.

Structured PICO

P
Population
BALB/c mice (male and female)
I
Intervention
Immunization with a cardiotropic strain of Coxsackie B-3 virus
C
Comparator
Immunization with a noncardiotropic strain of Coxsackie B-3 virus
O
Outcome
Cytolytic activity of spleen cells against uninfected myofiberssurrogate

The study reveals significant sex differences in the immune response to Coxsackievirus B-3 infection in mice, which may have implications for understanding the pathogenesis of viral myocarditis.

Cite This Study

Huber et al. (1981) studied this question.

synapsesocial.com/papers/6a7d2c8a86f53b502d964f7ehttps://doi.org/10.4049/jimmunol.126.4.1336
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Sex-related differences in the pattern of coxsackievirus B-3-induced immune spleen cell cytotoxicity against virus-infected myofibers1981 · 36 citations
  2. 2Generation of Cytotoxic T Lymphocytes during Coxsackievirus B-3 Infection1977 · 43 citations
  3. 3Generation of Cytotoxic T Lymphocytes during Coxsackievirus B-3 Infection1977 · 59 citations
  4. 4Differences in cytolytic T cell response of BALB/c mice infected with myocarditic and non-myocarditic strains of coxsackievirus group B, type 31983 · 55 citations
  5. 5Differential Th1 and Th2 cell responses in male and female BALB/c mice infected with coxsackievirus group B type 31994 · 250 citations