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April 1, 1981Infection and ImmunityOpen Access

Sex-related differences in the pattern of coxsackievirus B-3-induced immune spleen cell cytotoxicity against virus-infected myofibers

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Why the study?

Does sex influence immune spleen cell cytotoxicity against coxsackievirus B-3-infected myofibers in adult BALB/c mice?

Population

Adult BALB/c mice

Comparison

Intraperitoneal injection with purified… vs Female mice (sex-based comparison)

Design

Preclinical

Follow-up

7 days

Authors

SHSally A. HuberUniversity of VermontLJL P JobUniversity of VermontJWJack F. WoodruffState University of New York

Discussion

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Implication

May explain male predominance in coxsackievirus myocarditis; leaves open translation to human disease.

Structured PICO

Does sex influence immune spleen cell cytotoxicity against coxsackievirus B-3-infected myofibers in adult BALB/c mice?

P
Population
Adult BALB/c mice
I
Intervention
Intraperitoneal injection with purified coxsackievirus B-3
C
Comparator
Female mice (sex-based comparison)
O
Outcome
Immune spleen cell cytotoxicity against 51Cr-labeled syngeneic infected and uninfected myofiberssurrogate

The stronger effector cell response against infected myocardial cells in male mice correlates with the clinical observation that adult coxsackievirus B myocarditis occurs predominantly in males.

Cite This Study

Huber et al. (1981) studied this question.

synapsesocial.com/papers/6a846bb122c36ed33af7a061https://doi.org/10.1128/iai.32.1.68-73.1981
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Involvement of T Lymphocytes in the Pathogenesis of Coxsackie Virus B3 Heart Disease1974 · 315 citations
  2. 2MYOCARDITIS IN EXPERIMENTAL COXSACKIE B-3 INFECTION1959 · 53 citations
  3. 3THE MAMMALIAN CELL-VIRUS RELATIONSHIP1961 · 85 citations
  4. 4The Influence of Quantitated Post-Weaning Undernutrition on Coxsackievirus B3 Infection of Adult Mice. I. Viral Persistence and Increased Severity of Lesions1970 · 113 citations
  5. 5Coxsackie B-5 Pericarditis in Pregnancy1962 · 24 citations