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March 1, 1986The Journal of Immunology

Variations in the susceptibility to Coxsackievirus B3-induced myocarditis among different strains of mice.

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Population

Different inbred strains of mice (A.BY/SnJ, A.SW/SnJ, A.CA/SnJ, B10.S/SgSf, B10.PL/SgSf, and C3H.NB/SnJ)

Comparison

Coxsackievirus B3 infection vs Comparison among different inbred mouse strains

Design

Preclinical

Authors

LWLuanne J. WolfgramKBKirk W. BeiselAHA Herskowitz

Discussion

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Overview

Strain-specific murine susceptibility highlights MHC/non-MHC control of viral myocarditis; hypothesis-generating for human genetic risk, no practice change.

Structured PICO

P
Population
Different inbred strains of mice (A.BY/SnJ (H-2b), A.SW/SnJ (H-2s), A.CA/SnJ (H-2f), B10.S/SgSf (H-2s), B10.PL/SgSf (H-2u), and C3H.NB/SnJ (H-2p))
I
Intervention
Coxsackievirus B3 infection
C
Comparator
Comparison among different inbred mouse strains (MHC and non-MHC congenics)
O
Outcome
Extent and duration of viremia, temporal appearance and titer of neutralizing antibody, and prevalence, severity, and duration of myocardial diseasesurrogate

Genetic regulation, involving both MHC and non-MHC factors, determines the susceptibility to and progression of Coxsackievirus B3-induced myocarditis in mice.

Cite This Study

Wolfgram et al. (1986) studied this question.

synapsesocial.com/papers/6a72606935aa2c282ce33957https://doi.org/10.4049/jimmunol.136.5.1846
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Genetic control of Coxsackievirus B3-induced heart-specific autoantibodies associated with chronic myocarditis1991 · 21 citations
  2. 2Alterations in major histocompatibility complex association of myocarditis induced by coxsackievirus B3 mutants selected with monoclonal antibodies to group A streptococci.1994 · 44 citations
  3. 3Characterization and myocarditic capabilities of coxsackievirus B3 variants in selected mouse strains1984 · 68 citations
  4. 4Comparative immunoproteome analysis of the response of susceptible A.BY/SnJ and resistant C57BL/6 mice to Coxsackievirus B3-infection2012
  5. 5Coxsackievirus-induced chronic myocarditis in murine models1995 · 35 citations