Key result
Expression of MHC class II IE antigen in mice promoted substantial cardiac injury after Coxsackievirus B3 infection, a susceptibility mediated by specific gamma delta+ T cell subpopulations.
MHC class II IE antigen expression determines susceptibility to CVB3-induced myocarditis via activation of specific gamma delta+ T cell subpopulations that promote Th1 responses.
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MHC class II IE expression may influence CVB3 myocarditis severity in mice; leaves open relevance to human disease.
Huber et al. (1999) studied Coxsackievirus B3-Induced Autoimmune Myocarditis. MHC class II IE antigen expression vs. Mice lacking MHC class II IE antigen was evaluated on Myocarditis susceptibility and cardiac lesions. Expression of MHC class II IE antigen in mice promoted substantial cardiac injury after Coxsackievirus B3 infection, a susceptibility mediated by specific gamma delta+ T cell subpopulations.
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