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December 1, 1999Annals of the New York Academy of Sciences

Apoptosis in Coxsackievirus B3‐induced Myocarditis and Dilated Cardiomyopathy

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Population

Mouse model of Coxsackievirus B3-induced myocarditis and dilated cardiomyopathy

Design

Preclinical

Authors

SHSally A. HuberUniversity of VermontRBRalph C. BuddUniversity of VermontKRKenneth L. RossnerUniversity of Vermont

Discussion

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Implication

Does not support clinical translation in myocarditis; leaves open human relevance of gamma-delta T-cell modulation.

Structured PICO

P
Population
Mouse model of Coxsackievirus B3-induced myocarditis and dilated cardiomyopathy
I
Intervention
Coxsackievirus B3 infection and immune modulation by gamma-delta T cells
O
Outcome
Mechanism of immune modulation and T cell response phenotype

Gamma-delta T cells modulate the immune response in Coxsackievirus B3-induced myocarditis by selectively lysing CD4+ Th2 cells via Fas:FasL interaction, promoting a pathogenic Th1 phenotype.

Cite This Study

Huber et al. (1999) studied this question.

synapsesocial.com/papers/6a9555902dd91e6efbf22d4ehttps://doi.org/10.1111/j.1749-6632.1999.tb07932.x

Topics

Myocarditis
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Modulation of cytokine expression by CD4+ T cells during coxsackievirus B3 infections of BALB/c mice initiated by cells expressing the gamma delta + T-cell receptor1996 · 64 citations
  2. 2Augmentation of pathogenesis of coxsackievirus B3 infections in mice by exogenous administration of interleukin-1 and interleukin-21994 · 102 citations
  3. 3Selection of an attenuated Coxsackievirus B3 variant, using a monoclonal antibody reactive to myocyte antigen1991 · 64 citations
  4. 4Lymphocyte programmed cell death is mediated via HLA class II DR1994 · 106 citations
  5. 5The intensity of T cell receptor engagement determines the cytokine pattern of human allergen‐specific T helper cells1997 · 59 citations