Key result
Transfer of gamma delta+ T cells from H3-infected mice to H310A1-infected mice restored myocarditis susceptibility, shifted cytokine production to gamma interferon, and induced apoptosis.
Population
BALB/c mice infected with coxsackievirus B3 variants (H3 and H310A1)
Comparison
Transfer of 5,000 gamma delta+ T cells isolated… vs H310A1 virus-infected mice without cell transfer
Design
Preclinical
Authors
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Gamma delta T cells may mediate coxsackievirus myocarditis severity in mice; leaves open their role in human disease.
Gamma delta+ T cells modulate cytokine responses and induce apoptosis in CD4+ T cells during coxsackievirus B3 infection, influencing myocarditis susceptibility in a murine model.
Huber et al. (1996) studied Coxsackievirus B3 infection and myocarditis. Transfer of gamma delta+ T cells from H3 virus-infected mice vs. H310A1 virus-infected mice without cell transfer was evaluated on Myocarditis susceptibility, cytokine production pattern, and apoptosis. Transfer of gamma delta+ T cells from H3-infected mice to H310A1-infected mice restored myocarditis susceptibility, shifted cytokine production to gamma interferon, and induced apoptosis.
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