In a transgenic mouse model, TNF-induced left ventricular remodeling and collagen content changes are driven by an imbalance between MMP and TIMP activity.
MMP/TIMP imbalance drives TNF-induced LV collagen changes in mice; leaves open translation to human remodeling therapies.
Our results suggest that progressive time-dependent changes in the balance between MMP activity and TIMP activity are responsible, at least in part, for the spectrum of TNF-induced changes in the myofibrillar collagen content that occur during LV structural remodeling in the MHCsTNF mice.
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Sivasubramanian et al. (2001) studied this question.
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