Corticosteroid nasal irrigations are more effective than simple sprays in a randomized double‐blinded placebo‐controlled trial for chronic rhinosinusitis after sinus surgery

Richard J. Harvey; Kornkiat Snidvongs; Larry Kalish; Gretchen M. Oakley; Raymond Sacks

doi:10.1002/alr.22093

February 2, 2018International Forum of Allergy & Rhinology

Corticosteroid nasal irrigations are more effective than simple sprays in a randomized double‐blinded placebo‐controlled trial for chronic rhinosinusitis after sinus surgery

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Key Points

To determine whether corticosteroid delivered via nasal irrigation provides superior efficacy compared to a simple nasal spray in postsurgical chronic rhinosinusitis patients.
Conducted a randomized, double-blind, placebo-controlled trial.
Evaluated postsurgical patients presenting with diffuse or patchy chronic rhinosinusitis (CRS).
Compared topical corticosteroid administration delivered via nasal irrigation versus standard nasal spray.
Corticosteroid delivery by nasal irrigation was clinically superior to simple nasal spray administration in postsurgical patients.
Superior therapeutic benefits were specifically demonstrated across diffuse and patchy CRS disease distributions.

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Implication

Randomized double-blind placebo-controlled trial finds corticosteroid nasal irrigations superior to sprays in postsurgical chronic rhinosinusitis, highlighting improved drug delivery.

Abstract

In the setting of diffuse or patchy CRS disease, the use of corticosteroid delivered by nasal irrigation is superior to simple nasal spray in postsurgical patients.

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Harvey et al. (2018) studied this question.

synapsesocial.com/papers/69d8d2bbd2f7327e70ae4632 https://doi.org/10.1002/alr.22093

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Corticosteroid nasal irrigations are more effective than simple sprays in a randomized double‐blinded placebo‐controlled trial for chronic rhinosinusitis after sinus surgery

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Corticosteroid nasal irrigations are more effective than simple sprays in a randomized double‐blinded placebo‐controlled trial for chronic rhinosinusitis after sinus surgery

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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