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April 1, 2002Annual Review of Immunology

Molecular Mechanism of Class Switch Recombination: Linkage with Somatic Hypermutation

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Authors

Tasuku HonjoKanazawa University KKKazuo KinoshitaShizuoka University MMMasamichi MuramatsuKanazawa University

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Implication

Does not yet guide clinical management of B-cell disorders; leaves open validation of the proposed AID mechanism.

Key Points

Key points are not available for this paper at this time.

Cite This Study

Honjo et al. (2002) studied this question.

synapsesocial.com/papers/69d8d800b0225cae72beddc1 https://doi.org/10.1146/annurev.immunol.20.090501.112049

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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Switch recombination breakpoints occur at nonrandom positions in the S gamma tandem repeat.1993 · 37 citations
2IgA class switch in I alpha exon-deficient mice. Role of germline transcription in class switch recombination.1996 · 91 citations
3RNA: DNA complex formation upon transcription of immunoglobulin switch regions: implications for the mechanism and regualtion of class switch recombination1995 · 212 citations
4The Ig heavy chain intronic enhancer core region is necessary and sufficient to promote efficient class switch recombination1999 · 44 citations
5Specific Expression of Activation-induced Cytidine Deaminase (AID), a Novel Member of the RNA-editing Deaminase Family in Germinal Center B Cells1999 · 1,189 citations