What question did this study set out to answer?

To review the rising global incidence, contributing environmental and genetic factors, and unique diagnostic and therapeutic challenges of young-onset colorectal cancer.

April 27, 2023Nature Reviews Disease PrimersOpen Access

Young-onset colorectal cancer

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Authors

MSManon C.W. SpaanderErasmus MC AZAnn G. ZauberMemorial Sloan Kettering Cancer Center SSSapna SyngalDana-Farber Cancer Institute

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Implication

Review uncovers rising rates and unique environmental drivers of colorectal cancer in adults under 50, highlighting the urgent need for earlier screening and tailored therapies.

Key Points

To review the rising global incidence, contributing environmental and genetic factors, and unique diagnostic and therapeutic challenges of young-onset colorectal cancer.
Synthesized global epidemiological trends, genetic analyses, and lifestyle-related risk factors in patients diagnosed with colorectal cancer under age 50.
Evaluated diagnostic barriers, gut microbiome alterations, and clinical management strategies distinct to younger populations.
Young-onset colorectal cancer is projected to account for 11% of colon cancers and 23% of rectal cancers by 2030 across both sexes globally.
Hereditary cancer syndromes explain only 20% of young-onset cases, while the majority lack genetic predisposition and correlate with lifestyle-driven microbiome alterations, obesity, and antibiotic exposure.
Younger individuals frequently present with advanced-stage disease due to lack of routine screening, necessitating treatment adjustments to mitigate long-term therapeutic toxicities.

Cite This Study

Spaander et al. (2023) studied this question.

synapsesocial.com/papers/69d8e4b6183921ebcaae3e98 https://doi.org/10.1038/s41572-023-00432-7

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Implication

Review uncovers rising rates and unique environmental drivers of colorectal cancer in adults under 50, highlighting the urgent need for earlier screening and tailored therapies.

Young-onset colorectal cancer

Discussion

Member takes

Implication

Key Points

Cite This Study

Young-onset colorectal cancer

Discussion

Member takes

Implication

Key Points

Cite This Study

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