November 1, 1996Journal of the American Society of Nephrology

Actions of epoxygenase metabolites on the preglomerular vasculature.

View Full Paper

Ask AI

Bookmark

Population

In vitro blood-perfused juxtamedullary nephron preparation

Comparison

Superfusion with epoxyeicosatrienoic acids at… vs Baseline preconstricted state

Design

Preclinical

Authors

JIJohn D. ImigVascular Medicine LNL. Gabriel NavarVascular Medicine RRR. J. RomanUniversity of Mississippi Medical Center

Discussion

Member takes

Implication

Hypothesis-generating for divergent EET effects on renal arterioles; leaves open translation to human glomerular hemodynamics.

Structured PICO

Population

In vitro blood-perfused juxtamedullary nephron preparation (interlobular and afferent arterioles preconstricted with 0.5 microM norepinephrine)

Intervention

Superfusion with epoxyeicosatrienoic acids (5,6-EET, 8,9-EET, 11,12-EET, and 14,15-EET) at doses ranging from 0.01 to 100 nM

Comparator

Baseline preconstricted state

Outcome

Interlobular and afferent arteriolar diameter responsessurrogate

Epoxygenase metabolites of arachidonic acid exert divergent effects on preglomerular vasculature, with 11,12-EET causing direct vasodilation and 5,6-EET causing endothelium- and cyclooxygenase-dependent vasoconstriction.

Cite This Study

Imig et al. (1996) studied this question.

synapsesocial.com/papers/69d8eb7bade63f05b9bede73 https://doi.org/10.1681/asn.v7112364

View Full Paper

Ask AI

Bookmark