What question did this study set out to answer?

To determine whether lymphocyte migration through lymph nodes follows a circadian rhythm and to investigate how lymphocyte circadian clocks influence adaptive immune responses.

January 1, 2017ImmunityOpen Access

Lymphocyte Circadian Clocks Control Lymph Node Trafficking and Adaptive Immune Responses

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To determine whether lymphocyte migration through lymph nodes follows a circadian rhythm and to investigate how lymphocyte circadian clocks influence adaptive immune responses.
Monitored lymphocyte homing to and egress from lymph nodes and efferent lymphatic fluid across 24-hour cycles.
Used lineage-specific genetic ablation to disrupt circadian clock function in T cells.
Induced experimental autoimmune encephalomyelitis through immunization at different times of day to assess diurnal variation in disease severity.
Lymphocyte homing into lymph nodes peaked at night onset, whereas cell exit occurred during the day, producing pronounced diurnal oscillations in lymph node cellularity and lymphatic fluid.
Trafficking rhythms were driven cell-intrinsically by circadian-dependent rhythmic expression of promigratory factors and coincided with cyclic dendritic cell accumulation.
Genetic ablation of T cell clocks abolished diurnal differences in experimental autoimmune encephalomyelitis severity, showing that the time of day of antigen exposure shapes adaptive immunity.

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Implication

Experimental study demonstrates circadian rhythmicity in lymphocyte lymph node trafficking, highlighting how immunization timing alters adaptive immunity.

Cite This Study

Druzd et al. (2017) studied this question.

synapsesocial.com/papers/69d8ed441ab91f1400bed8c5 https://doi.org/10.1016/j.immuni.2016.12.011

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Implication

Experimental study demonstrates circadian rhythmicity in lymphocyte lymph node trafficking, highlighting how immunization timing alters adaptive immunity.

Lymphocyte Circadian Clocks Control Lymph Node Trafficking and Adaptive Immune Responses

Key Points

Discussion

Implication

Cite This Study

Lymphocyte Circadian Clocks Control Lymph Node Trafficking and Adaptive Immune Responses

Key Points

Discussion

Implication

Cite This Study

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