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February 26, 2009Microbiology

Short motif sequences determine the targets of the prokaryotic CRISPR defence system

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Population

Prokaryotic CRISPR defence systems, including Streptococcus thermophilus

Design

Preclinical

Authors

FMFrancisco J. M. MojicaUniversity of AlicanteCDCésar Díez‐VillaseñorUniversity of JyväskyläJGJesús García‐MartínezHospital Universitario de Fuenlabrada

Discussion

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Implication

PAM conservation may guide CRISPR tool selection in research; leaves open translation to cardiovascular gene editing.

Structured PICO

P
Population
Prokaryotic CRISPR defence systems, including Streptococcus thermophilus
O
Outcome
Role of proto-spacer adjacent motifs (PAMs) in spacer uptake and target determination

Identifies that proto-spacer adjacent motifs (PAMs) are conserved across diverse CRISPR systems and determine the specific choice and orientation of spacers.

Cite This Study

Mojica et al. (2009) studied this question.

synapsesocial.com/papers/69d8ef6c8c03fbaff8bf01d5https://doi.org/10.1099/mic.0.023960-0
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Evolutionary conservation of sequence and secondary structures in CRISPR repeats2007 · 462 citations
  2. 2Diversity, Activity, and Evolution of CRISPR Loci in Streptococcus thermophilus2007 · 811 citations
  3. 3A Novel Family of Sequence-specific Endoribonucleases Associated with the Clustered Regularly Interspaced Short Palindromic Repeats2008 · 204 citations
  4. 4Long stretches of short tandem repeats are present in the largest replicons of the Archaea Haloferax mediterranei and Haloferax volcanii and could be involved in replicon partitioning1995 · 309 citations
  5. 5Biological significance of a family of regularly spaced repeats in the genomes of Archaea, Bacteria and mitochondria2000 · 838 citations