Why the study?
Does prior evidence of diabetes increase the risk of cardiovascular events in the Framingham cohort?
Population
Framingham cohort
Comparison
Prior evidence of diabetes vs Nondiabetic individuals
Design
Cohort
Follow-up
20 years
Authors
Discussion
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Member takes
Implication
Diabetes associated with 2-3× atherosclerotic risk; leaves open causal inference and generalizability beyond Framingham.
Structured PICO
Does prior evidence of diabetes increase the risk of cardiovascular events in the Framingham cohort?
P
Population
Framingham cohort
I
Intervention
Prior evidence of diabetes
C
Comparator
Nondiabetic individuals
O
Outcome
Cardiovascular events (clinical atherosclerotic disease, including intermittent claudication, congestive heart failure, coronary heart disease, stroke, and cardiovascular death)hard clinical
Diabetes confers a twofold to threefold increased risk of clinical atherosclerotic disease, with a particularly high relative impact on cardiovascular mortality and heart failure in women.
Cite This Study
William B. Kannel (1979) studied this question.