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Review advances in understanding how the evolutionarily conserved TOR kinase, specifically mammalian TOR (mTOR), regulates the molecular machinery of autophagy in response to nutrient and stress signals.

January 18, 2010FEBS Letters

mTOR regulation of autophagy

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Authors

CJChang Hwa JungKorea Food Research Institute SRSeung‐Hyun RoUniversity of Nebraska–Lincoln JCJing CaoKunming University of Science and Technology

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Implication

Review reveals how mTOR kinase governs the autophagy machinery in eukaryotic cells, highlighting the molecular balance between nutrient signaling and cellular degradation.

Key Points

Review advances in understanding how the evolutionarily conserved TOR kinase, specifically mammalian TOR (mTOR), regulates the molecular machinery of autophagy in response to nutrient and stress signals.
Synthesized molecular and biochemical literature detailing the function of TOR as a nutrient-sensing protein kinase in eukaryotic cell growth control.
Evaluated regulatory interactions between mammalian TOR (mTOR) signaling pathways and core autophagy machinery components during nutrient abundance and starvation.
TOR acts as an essential sensor that balances cell growth and catabolic recycling in response to nutritional status, growth factors, and cellular stress.
Nutrient starvation directly inhibits mTOR activity, triggering the downstream activation of the autophagy machinery to enable cellular survival.

Cite This Study

Jung et al. (2010) studied this question.

synapsesocial.com/papers/69d8f2f3e72b319804d17cda https://doi.org/10.1016/j.febslet.2010.01.017

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Implication

Review reveals how mTOR kinase governs the autophagy machinery in eukaryotic cells, highlighting the molecular balance between nutrient signaling and cellular degradation.

mTOR regulation of autophagy

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Implication

Key Points

Cite This Study

mTOR regulation of autophagy

Discussion

Member takes

Implication

Key Points

Cite This Study

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