Why the study?
Are clinical markers and advanced glycation end products associated with early reduced diastolic heart function in children and adolescents with type 1 diabetes?
Are clinical markers and advanced glycation end products associated with early reduced diastolic heart function in children and adolescents with type 1 diabetes?
In children with T1D, early reduced diastolic function is associated with higher BMI, while trends toward elevated advanced glycation end products (MG-H1) and vascular stiffness were not statistically significant after adjustment.
Higher BMI was associated with early diastolic dysfunction in T1D youth; leaves open contributions from MG-H1 or carotid stiffness, needing prospective studies.
Early signs of reduced diastolic function in children and adolescents with T1D had higher BMI, but not higher HbA1c. They also had elevated serum levels of the advanced glycation end product MG-H1, higher blood pressure and increased stiffness of the common carotid artery, but these associations did not reach statistical significance when tested in a logistic regression model.
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Brunvand et al. (2017) studied this question.
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