Key result
Children and adolescents with type 1 diabetes mellitus exhibited early signs of reduced myocardial diastolic function, demonstrated by a significantly lower overall mean mitral E'/A'-ratio of 2.3 compared to 2.7 in healthy controls (p<0.001).
Population
173 children and adolescents with type 1 diabetes mellitus without other known complications, mean diabetes…
Design
Cross-sectional
Authors
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May signal early cardiac involvement in pediatric T1DM; hypothesis-generating and should not yet change practice.
Case-Control (n=235)
Absolute Event Rate: 2.3% vs 2.7%
p-value: p=<0.001
Children and adolescents with type 1 diabetes exhibit early echocardiographic signs of reduced diastolic myocardial function despite short disease duration and modern intensive insulin treatment.
Brunvand et al. (2016) conducted a case-control in Type 1 diabetes mellitus (n=235). Type 1 diabetes mellitus vs. Healthy age-matched controls was evaluated on Overall mean mitral E'/A'-ratio (p=<0.001). Children and adolescents with type 1 diabetes mellitus exhibited early signs of reduced myocardial diastolic function, demonstrated by a significantly lower overall mean mitral E'/A'-ratio of 2.3 compared to 2.7 in healthy controls (p<0.001).
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