Key result
Children and adolescents with type 1 diabetes exhibited echocardiographic evidence of subclinical diastolic dysfunction, including significantly prolonged right ventricular isovolumic relaxation time compared to healthy controls (43.8 vs 35.76 ms, p=0.001).
Why the study?
Does Type 1 Diabetes cause echocardiographic diastolic dysfunction in children and adolescents compared to healthy controls?
Cross-Sectional (n=82)
No
Does Type 1 Diabetes cause echocardiographic diastolic dysfunction in children and adolescents compared to healthy controls?
Children and adolescents with Type 1 Diabetes for over 5 years show evidence of diastolic dysfunction on echocardiography, suggesting a potential need for periodic cardiac screening.
BACKGROUND: Cardiac dysfunction in patients with type 1 diabetes (T1D) represents one of the serious complications. To evaluate the cardiac function in children with T1D by conventional echocardiography and tissue Doppler imaging (TDI). METHODS: The study included 40 T1D patients (age between 6 and 16 years) with > 5 years duration of diabetes and 42 healthy control children. The patients were subjected to clinical evaluation and laboratory investigations [glycosylated hemoglobin A1c (HbA1c), serum lipids and lipoproteins]. Conventional echocardiography and TDI were performed to patients and controls. RESULTS: wave 0.047 and 0.015). No correlation existed between the duration of illness or the level of HbA1c and the echocardiographic parameters. CONCLUSION: Diabetic children have evidence of echocardiographic diastolic dysfunctions. Periodic cardiac evaluation with both conventional and tissue Doppler echocardiography is recommended for early detection of this dysfunction.
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Aziz et al. (2017) conducted a cross-sectional in Type 1 Diabetes (n=82). Type 1 Diabetes vs. Healthy controls was evaluated on Right ventricular isovolumic relaxation time (RV-IRT) in milliseconds (p=0.001). Children and adolescents with type 1 diabetes exhibited echocardiographic evidence of subclinical diastolic dysfunction, including significantly prolonged right ventricular isovolumic relaxation time compared to healthy controls (43.8 vs 35.76 ms, p=0.001).
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