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May 1, 2002Journal of Clinical InvestigationOpen Access

SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver

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Authors

JHJay D. HortonLaboratory of Molecular Genetics
Joseph L. Goldstein
Joseph L. GoldsteinThe University of Texas Southwestern Medical CenterMBMichael S. BrownHospital of the University of Pennsylvania

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Horton et al. (2002) studied this question.

synapsesocial.com/papers/69d8f433a5ecc596b5d18d34https://doi.org/10.1172/jci0215593
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Nutritional and insulin regulation of fatty acid synthetase and leptin gene expression through ADD1/SREBP1.1998 · 781 citations
  2. 2Sterol Regulatory Element-binding Protein-1 as a Key Transcription Factor for Nutritional Induction of Lipogenic Enzyme Genes1999 · 687 citations
  3. 3Sterol regulatory element binding protein-1c is a major mediator of insulin action on the hepatic expression of glucokinase and lipogenesis-related genes1999 · 749 citations
  4. 4Nonalcoholic Fatty Liver Disease2001 · 2,595 citations
  5. 5Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a.1996 · 823 citations