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January 23, 1981Science

Two Novel Classes of Small Ribonucleoproteins Detected by Antibodies Associated with Lupus Erythematosus

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Population

Uninfected cells and adenovirus-infected cells

Design

Preclinical

Authors

MLMichael R. LernerHoward Hughes Medical InstituteJBJohn A. BoyleYale UniversityJHJohn HardinTufts University

Discussion

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Implication

Animal characterization of Ro/La ribonucleoproteins leaves open their pathogenic roles and diagnostic utility in human lupus.

Structured PICO

P
Population
Uninfected cells and adenovirus-infected cells
I
Intervention
Antibodies associated with Lupus Erythematosus
O
Outcome
Characterization of small ribonucleoproteins associated with Ro and La antigens

Identifies that Ro and La antigens recognized by lupus antibodies are ribonucleoproteins with distinct small RNA profiles.

Cite This Study

Lerner et al. (1981) studied this question.

synapsesocial.com/papers/69d8f6a017a1cc0598d18fachttps://doi.org/10.1126/science.6164096
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Resolution of the identity of certain antigen‐antibody systems in systemic lupus erythematosus and sjögren's syndrome: An interlaboratory collaboration1979 · 220 citations
  2. 2Antibodies to small nuclear RNAs complexed with proteins are produced by patients with systemic lupus erythematosus1979 · 1,192 citations
  3. 3Characteristics of a soluble nuclear antigen precipitating with sera of patients with systemic lupus erythematosus2001 · 550 citations
  4. 4Characteristics of a Soluble Nuclear Antigen Precipitating with Sera of Patients with Systemic Lupus Erythematosus1966 · 482 citations
  5. 5A soluble acidic protein of the cell nucleus which reacts with serum from patients with systemic lupus erythermatosus and Sjögren's syndrome.1977 · 126 citations