Why the study?
Does Neuregulin-1β Glial Growth Factor 2 prevent adverse remodeling and fibrosis in a large animal model of heart failure?
Does Neuregulin-1β Glial Growth Factor 2 prevent adverse remodeling and fibrosis in a large animal model of heart failure?
GGF2/NRG-1β prevents adverse remodeling and exhibits anti-fibrotic effects in a large animal model of heart failure.
Supports GGF2/NRG-1β development in HF models; leaves open translation of anti-fibrotic effects to patients.
These results suggest that GGF2/NRG-1β prevents adverse remodeling after injury in part via anti-fibrotic effects in the heart.
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Galindo et al. (2014) studied this question.
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