February 15, 1998Journal of Clinical InvestigationOpen Access

Nitric oxide, atrial natriuretic peptide, and cyclic GMP inhibit the growth-promoting effects of norepinephrine in cardiac myocytes and fibroblasts.

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Population

Ventricular cells (myocytes and fibroblasts) cultured from neonatal rat heart

Comparison

Atrial natriuretic peptide, NO donor… vs Norepinephrine alone

Design

Preclinical

Authors

ACAngelino CalderoneMontreal Heart Institute CTCynthia M. ThaikHolistic Management International NTNaoya TakahashiBoston University

Discussion

Member takes

Implication

Hypothesis-generating for cGMP-mediated antihypertrophic signaling; leaves open translation to human cardiac remodeling.

Structured PICO

Population

Ventricular cells (myocytes and fibroblasts) cultured from neonatal rat heart

Intervention

Atrial natriuretic peptide (ANP), NO donor S-nitroso-N-acetyl-D,L-penicillamine (SNAP), and cGMP analogue 8-bromo-cGMP

Comparator

Norepinephrine alone

Outcome

Norepinephrine-stimulated incorporation of [3H]leucine in myocytes and [3H]thymidine in fibroblastssurrogate

Nitric oxide and atrial natriuretic peptide attenuate the growth-promoting effects of norepinephrine in cardiac cells, likely through cGMP-mediated inhibition of calcium influx.

Cite This Study

Calderone et al. (1998) studied this question.

synapsesocial.com/papers/69d8f7181ab91f1400beddf0 https://doi.org/10.1172/jci119883

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Nitric oxide, atrial natriuretic peptide, and cyclic GMP inhibit the growth-promoting effects of norepinephrine in cardiac myocytes and fibroblasts.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Nitric oxide, atrial natriuretic peptide, and cyclic GMP inhibit the growth-promoting effects of norepinephrine in cardiac myocytes and fibroblasts.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider