Natriuretic peptides inhibit angiotensin II-induced proliferation of rat cardiac fibroblasts by blocking endothelin-1 gene expression, suggesting a protective role against cardiac fibrosis.
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ANP/BNP may attenuate rat cardiac fibroblast proliferation; hypothesis-generating for antifibrotic effects in human HF.
Fujisaki et al. (1995) studied this question.
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