What question did this study set out to answer?

To identify and isolate T-cell receptors reactive against common oncogenic KRAS mutations presented by human leukocyte antigen molecules for cancer immunotherapy.

January 11, 2016Cancer Immunology ResearchOpen Access

Identification of T-cell Receptors Targeting KRAS-Mutated Human Tumors

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To identify and isolate T-cell receptors reactive against common oncogenic KRAS mutations presented by human leukocyte antigen molecules for cancer immunotherapy.
Screened mutated KRAS variants for HLA-A*11:01 binding potential using HLA-peptide prediction algorithms.
Immunized HLA-A*11:01 transgenic mice to isolate high-reactivity T-cell receptors targeting KRAS G12V and G12D variants.
Transduced human peripheral blood lymphocytes with candidate receptors and evaluated antitumor efficacy in an NSG mouse xenograft model bearing established pancreatic tumors.
Peripheral blood lymphocytes transduced with the isolated receptors successfully recognized multiple HLA-A*11:01-positive tumor cell lines carrying KRAS G12D or G12V mutations.
Adoptive transfer of engineered lymphocytes significantly suppressed established tumor growth in an HLA-A*11:01-positive, KRAS G12D pancreatic cancer xenograft model (P = 0.002).

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Implication

Preclinical study demonstrates regression of KRAS-mutated pancreatic tumors via engineered T-cell receptors in mouse models, highlighting therapeutic potential for common human cancers.

Cite This Study

Wang et al. (2016) studied this question.

synapsesocial.com/papers/69d8fb7d98a648f070ae2a7e https://doi.org/10.1158/2326-6066.cir-15-0188

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Implication

Preclinical study demonstrates regression of KRAS-mutated pancreatic tumors via engineered T-cell receptors in mouse models, highlighting therapeutic potential for common human cancers.

Identification of T-cell Receptors Targeting KRAS-Mutated Human Tumors

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Discussion

Implication

Cite This Study

Identification of T-cell Receptors Targeting KRAS-Mutated Human Tumors

Key Points

Discussion

Implication

Cite This Study

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