Why the study?
Does levosimendan 24-hour continuous infusion improve hemodynamics in patients with severe heart failure?
Does levosimendan 24-hour continuous infusion improve hemodynamics in patients with severe heart failure?
The prolonged hemodynamic effects of a 24-hour levosimendan infusion in severe heart failure are likely mediated by an active metabolite with a long half-life.
May warrant extended post-infusion monitoring in severe HF; leaves open metabolite-guided dosing optimization in trials.
A 24-hour infusion of levosimendan induces hemodynamic effects lasting several days after stopping the infusion. The prolongation of the effects beyond the infusion period is most likely due to an active metabolite with a long half-life.
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Kivikko et al. (2002) studied this question.