Why the study?
Does electroconvulsive therapy (ECT) increase seizure threshold and is it related to clinical response?
Does electroconvulsive therapy (ECT) increase seizure threshold and is it related to clinical response?
A rise in seizure threshold during ECT is not essential for therapeutic effect but may indicate underlying neuroplastic changes.
Seizure threshold changes should not guide ECT response expectations in practice; leaves open its potential as a neuronal state marker for prospective study.
Electroconvulsive therapy confers anticonvulsant effects in a consecutive sample of real-life patients. Neither initial seizure threshold nor magnitude of seizure threshold increase is a predictor of clinical response to ECT. A rise in seizure threshold is not essential for therapeutic effect but may represent an important marker of underlying neuronal state. The evidence reviewed in this article supports a link between neuroplastic effects of ECT and the evidenced rise in seizure threshold.
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Duthie et al. (2015) studied this question.
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