Cohort study reveals antepartum beta-cell dysfunction and obesity predict diabetes risk five years after gestational diabetes, highlighting targets for prevention.
Impaired beta-cell function and obesity at diagnosis of GDM were associated with the development of diabetes during a 5-yr, follow-up period. Studies designed to prevent diabetes in this high-risk group should examine strategies to maintain both optimal beta-cell function and maximum insulin sensitivity.
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Metzger et al. (1993) studied this question.
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